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J64258 N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin

CAS Number
211990-57-7
Synonyms
Ac-IETD-AFC

Stock No. Size Price ($) Quantity Availability
J64258-#0 5mg 169.00
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N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin

MDL
MFCD02094703

Chemical Properties

Formula
C31H38F3N5O12
Formula Weight
729.65
Form
Lyophilized powder
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in DMSO

Applications

N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Literature References

Markus Selzner; Hannes A.Rudiger; Nazia Selzner; Dennis W.Thomas; David Sindram; Pierre-Alain Clavien. Transgenic mice overexpressing human Bcl-2 are resistant to hepatic ischemia and reperfusion. Journal of Hepatology. 2002, 36,(2), 218-225.

 

Nazia Selzner; Markus Selzner; Wolfram Jochum; Pierre-Alain Clavien. Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: an ATP dependent mechanism. Journal of Hepatology. 2003, 39,(1), 55-61.

Other References

Harmonized Tariff Code
2932.20
TSCA
No

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