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581-05-5 - alpha-Melanocyte Stimulating Hormone amide - alpha-MSH amide - J64310 - Alfa Aesar

J64310 alpha-Melanocyte Stimulating Hormone amide

CAS Number
581-05-5
Synonyms
alpha-MSH amide

Size Price ($) Quantity Availability
1mg 40.80
5mg 97.80
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alpha-Melanocyte Stimulating Hormone amide

MDL
MFCD00133062

Chemical Properties

Formula
C77H109N21O19S
Formula Weight
1664.88
Form
Solid
Solubility
Soluble in water (~1 mg/ml).

Applications

alpha-Melanocyte Stimulating Hormone amide is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Literature References

D.M.Jacobowitz; T.L.O'Donohue. alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain. Current Issue. 1978, 75,(12), 6300-6304.

 

J.G.Cannon; J.B.Tatro; S.Reichlin; C.A.Dinarello. Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1. The Journal of Immunology. 1986, 137,(7), 2232-2236.

Other References

Harmonized Tariff Code
2937.19
TSCA
No

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