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50-63-5 - Chloroquine diphosphate salt, 98% - N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt - J64459 - Alfa Aesar

J64459 Chloroquine diphosphate salt, 98%

CAS Number
50-63-5
Synonyms
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

Size Price ($) Quantity Availability
25g 51.30
50g 87.75
100g 145.10
250g 272.00
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Chloroquine diphosphate salt, 98%

MDL
MFCD00069852
EINECS
200-055-2

Chemical Properties

Formula
C18H26ClN3.2H3PO4
Formula Weight
515.87
Form
Powder
Melting point
213-216°
Solubility
Soluble in water

Applications

Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 µM.

Notes

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Literature References

Maria Cristina Gaudiano.; Eleonora Antoniella.; Paola Bertocchi.; Luisa Valvo. Development and validation of a reversed-phase LC method for analyzing potentially counterfeit antimalarial medicines. Journal of Pharmaceutical and Biomedical Analysis. 2006, 42, (1), 132-135.

Minchinton, R.M.; Waters, A.H. Chloroquine stripping of HLA antigens from neutrophils without removal of neutrophil specific antigens. British Journal of Haematology. 1984, 57, (4), 703-706.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2163
Beilstein
4223142
Harmonized Tariff Code
2933.49
TSCA
No
RTECS
VB2450000

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