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The Apo-AI protein promotes fat efflux, including cholesterol, from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathicamyloidosis. Apo A-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect.Apolipoprotein A-I, human plasma is activated lecithin-cholesterol (LCAT) acyltransferase, which is responsible for cholesterol esterification in plasma. Further, it is a major protein component in high density lipoprotein.
Franceschini, G.; Sirtori, M.; Gianfranceschi, G.; Sirtori, C. R. Relation between the HDL apoproteins and A-I isoproteins in subjects with the AIMilano abnormalityMetab. Clin. Exp. 1981, 30 (5), 502-509.
Mendivil, C. O.; Furtado, J.; Morton, A. M.; Wang, L.; Sacks, F. M. Novel Pathways of Apolipoprotein A-I Metabolism in High-Density Lipoprotein of Different Sizes in Humans. Arterioscler. Thromb. Vasc. Biol. 2016, 36 (1), 156-165.
Handa, D.; Kimura, H.; Oka, T.; Takechi, Y.; Okuhira, K.; Phillips, M. C.; Saito, H. Kinetic and Thermodynamic Analyses of Spontaneous Exchange between High-Density Lipoprotein-Bound and Lipid-Free Apolipoprotein A-I. Biochemistry 2015, 54 (4), 1123-1131.