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Bolton-Hunter Reagent is used for iodination of proteins that do not contain tyrosine residues, Bolton-Hunter reagent precursor (3-(4-Hydroxyphenyl)propionic acid N-hydroxysuccinimide ester) is a hydroxysuccinimide ester used as an intermediate for high radioactive radioiodination of proteins.
Georges Gaudriault.; Jean-Pierre Vincent. Selective labeling of α- or ?-amino groups in peptides by the Bolton-Hunter reagent. Peptides. 1992, 13, (6), 1187-1192.
Carlier, M.F.; Simon, C.; Pantaloni, D. Radioiodination of brain tubulin with Bolton-Hunter reagent. Biochemical and Biophysical Research Communications. 1980, 96, (4), 1761-1767.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.