Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

J64538 Cerulenin, 98%

CAS Number
17397-89-6
Synonyms
(2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide

Stock No. Size Price ($) Quantity Availability
J64538-#0 5mg 122.00
J64538-MA 10mg 241.00
Add to Cart Bulk/Specialty Print Quote View Item

Cerulenin, 98%

MDL
MFCD00077686
EINECS
241-424-8

Chemical Properties

Formula
C12H17NO3
Formula Weight
223.27
Form
Powder
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in acetone at 20mg/ml. Also soluble in ethanol, benzene, chloroform, or ethyl acetate.

Applications

Cerulenin is used as an antifungal antibiotic that inhibits sterol and fatty acids biosynthesis. Cerulenin induces apoptosis in tumor cell lines. It can be a useful biochemical tool with applications for the study of metabolism and function of fatty acids in the bacterial cell membrane and in yeast. An extensive review including the properties, uses, mechanism of action and structure has been reported.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers..

Literature References

Sakari Kauppinen.; Mads Siggaard-Andersen.; Penny von Wettstein-Knowles. β-ketoacyl-ACP synthase I of Escherichia coli: Nucleotide sequence of thefabB gene and identification of the cerulenin binding residue. Carlsberg Research Communications. 1988, 53, (6), 357-370.

Giuliano D'agnony.; Ira S. Rosenfeld.; Juichi Awaya.; Satoshi Omura.; Roy Vagelos, P. Inhibition of fatty acid synthesis by the antibiotic cerulenin: Specific inactivation of β-ketoacyl-acyl carrier protein synthesize. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1973, 326, (2), 155-166.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264b-P270-P301+P312-P330-P501c

Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2004
Beilstein
4140423
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
JR1670000

Recommended

  • 41549

    Fullerene, buckytube/nanotube, multi-walled, ground core, 7-12nm OD, 0.5-10 micron long
  • L01642

    N,N-Dimethylacetamide dimethyl acetal, tech. 90%, stab with 5-10% methanol
  • B22131

    N-Phenylethanolamine, 98%
  • 45267

    Titanium, plasma standard solution, Specpure®, Ti 10µg/ml
  • L03738

    Triethylsilanol, 97%

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware