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17397-89-6 - Cerulenin, 98% - (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide - J64538 - Alfa Aesar

J64538 Cerulenin, 98%

CAS Number
17397-89-6
Synonyms
(2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide

Size Price ($) Quantity Availability
5mg 113.00
10mg 221.00
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Cerulenin, 98%

MDL
MFCD00077686
EINECS
241-424-8

Chemical Properties

Formula
C12H17NO3
Formula Weight
223.27
Form
Powder
Solubility
Soluble in acetone at 20mg/ml. Also soluble in ethanol, benzene, chloroform, or ethyl acetate.

Applications

Cerulenin is used as an antifungal antibiotic that inhibits sterol and fatty acids biosynthesis. Cerulenin induces apoptosis in tumor cell lines. It can be a useful biochemical tool with applications for the study of metabolism and function of fatty acids in the bacterial cell membrane and in yeast. An extensive review including the properties, uses, mechanism of action and structure has been reported.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers..

Literature References

Sakari Kauppinen.; Mads Siggaard-Andersen.; Penny von Wettstein-Knowles. β-ketoacyl-ACP synthase I of Escherichia coli: Nucleotide sequence of thefabB gene and identification of the cerulenin binding residue. Carlsberg Research Communications. 1988, 53, (6), 357-370.

Giuliano D'agnony.; Ira S. Rosenfeld.; Juichi Awaya.; Satoshi Omura.; Roy Vagelos, P. Inhibition of fatty acid synthesis by the antibiotic cerulenin: Specific inactivation of β-ketoacyl-acyl carrier protein synthesize. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1973, 326, (2), 155-166.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2004
Beilstein
4140423
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
JR1670000

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