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Azadibenzocyclooctyne acid - ADIBO-acid - J64549 - Alfa Aesar

J64549 Azadibenzocyclooctyne acid

CAS Number

Size Price ($) Quantity Availability
25mg 145.00
100mg 374.00
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Azadibenzocyclooctyne acid


Chemical Properties

Formula Weight
Soluble in dimethyl sulfoxide and dimethyl formamide.


Azadibenzocyclooctyne acid is the simplest amine reactive reagent for introducing a dibenzylcyclooctyne to available amine functionality.Azadibenzocyclooctyne acid is widely useful in strain-promoted copper-free azide-alkyne click chemistry reactions. It reacts with azide functionalized compounds or bimolecules to give stable triazole linkage without a need for a Cu(I) catalyst.


Store in cool place. Incompatible with amines.

Literature References

Patterson, D. M.; Prescher, J. A. Orthogonal bioorthogonal chemistries. Curr. Opin. Chem. Biol. 2015, 28, 141-149.

Jung, S.; Yi, H. Integrated fabrication-conjugation approaches for biomolecular assembly and protein sensing with hybrid microparticle platforms and biofabrication - A focused minireview. Korean J. Chem. Eng. 2015, 32 (9), 1713-1719.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • A13027

    3,4-Dimethylphenylhydrazine hydrochloride, 98%
  • B23727

    Dibenzosuberenone, 97%
  • H27711

    (S)-(+)-2-Indolinemethanol, 98+%
  • L06866

    Cumene hydroperoxide, tech. 80%
  • J64128

    Azadibenzocyclooctyne-NHS ester, with 4 carbon linker

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