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Z-Asp-Glu-Val-Asp-7-amino-4-(trifluoromethyl)coumarin - Z-DEVD-AFC - Z-Asp-Glu-Val-Asp-AFC - J64569 - Alfa Aesar

J64569 Z-Asp-Glu-Val-Asp-7-amino-4-(trifluoromethyl)coumarin

CAS Number
Synonyms
Z-DEVD-AFC
Z-Asp-Glu-Val-Asp-AFC

Size Price ($) Quantity Availability
5mg 120.00
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Z-Asp-Glu-Val-Asp-7-amino-4-(trifluoromethyl)coumarin

MDL
MFCD01074977

Chemical Properties

Formula
C36H38F3N5O14
Formula Weight
821.71
Form
Powder
Solubility
Soluble in dimethyl sulfoxide.

Applications

Z-Asp-Glu-Val-Asp-7-amino-4-(trifluoromethyl)coumarin acts as a substrate for granzyme B-processed ICE-LAP3, caspase-6, caspase-7, caspase-8, and caspase-10. The reaction can be observed by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Jiuru Sun.; Stephen P. Bottomley.; Sharad Kumar.; Phillip I. Bird. Recombinant Caspase-3 Expressed inPichia pastorisIs Fully Activated and Kinetically Indistinguishable from the Native Enzyme. Biochemical and Biophysical Research Communications. 1997, 238 (3), 920-924.

Kieran F. Harvey.; Natasha L. Harvey.; Julie M. Michael.; Gayathri Parasivam.; Nigel Waterhouse.; Emad S. Alnemri?.; Dianne Watters.; Sharad Kumar. Caspase-mediated Cleavage of the Ubiquitin-protein Ligase Nedd4 during Apoptosis. The Journal of Biological Chemistry. 1998, 273 13524-13530.

Other References

Harmonized Tariff Code
2932.20
TSCA
No

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