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28822-58-4 - 3-Isobutyl-1-methylxanthine - 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione - Phosphodiesterase Inhibitor (IBMX) - J64598 - Alfa Aesar

J64598 3-Isobutyl-1-methylxanthine

CAS Number
28822-58-4
Synonyms
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Phosphodiesterase Inhibitor (IBMX)

Size Price ($) Quantity Availability
100mg 47.17
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3-Isobutyl-1-methylxanthine

MDL
MFCD00005584
EINECS
249-259-3

Chemical Properties

Formula
C10H14N4O2
Formula Weight
222.24
Form
Solid
Melting point
200-201°
Solubility
Soluble in ethanol.

Applications

3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.

Notes

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Literature References

Stephen C. Mann.; Paul A. Andrews.; Stephen B. Howell. Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells. International Journal of Cancer. 1991, 48, (6), 866-872.

Friedman, G.; Chajek-Shaul, T.; Stein, O.; Stein, Y. Modulation of lipoprotein lipase activity in cultured rat mesenchymal heart cells and preadipocytes by dibutyryl cyclic amp, cholera toxin and 3-isobutyl- 1-methylxanthine. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1983, 752, (1), 106-117.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.59
TSCA
No
RTECS
ZD8500000

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