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2?-Deoxyuridine 5?-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 220.127.116.11) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
Ruth L. Saxl.; James Reston.; Zhe Nie.; Thomas I. Kalman.; Frank Maley. Modification of Escherichia coli Thymidylate Synthase at Tyrosine-94 by 5-Imidazolylpropynyl-2-deoxyuridine 5-Monophosphate. Biochemistry. 2003, 42 (15), 4544-4551.
Mikhail V. Rekharsky.; Asao Nakamura.; Guy A. Hembury.; Yoshihisa Inoue. Thermodynamic Study of the Discrimination between Uridine and Thymidine Derivatives by Hydrophobic, Stacking, and Intercalating Interactions. Bulletin of the Chemical Society of Japan. 2001, 74 (3), 449-457.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.