Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

49843-98-3 - EX 527 - 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide - J64753 - Alfa Aesar

J64753 EX 527

CAS Number

Size Price ($) Quantity Availability
10mg 123.60
Add to Cart Add to Quote Request View Item

EX 527


Chemical Properties

Formula Weight
Soluble in dimethyl sulfoxide, ethanol and dimethyl formamide.


EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive.


Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Marcus Freitag.; Jorg Schemies.; Tim Larsen.; Khattab El Gaghlab.; Felix Schulz.; Tobias Rumpf.; Manfred Jung.; Andreas Link. Synthesis and biological activity of splitomicin analogs targeted at human NAD+-dependent histone deacetylases (sirtuins). Cell Calcium. 2011 19, (12), 3669-3677.

Mohosin Layek.; Y. Syam Kumar.; Aminul Islam.; Ravikumar Karavarapu.; Amrita Sengupta.; Devyani Halder.; K. Mukkanti.; Manojit Pal. Alkynylation of N-(3-iodopyridin-2-yl)sulfonamide under Pd/C-Cu catalysis: a direct one pot synthesis of 7-azaindoles and their pharmacological evaluation as potential inhibitors of sirtuins. 2011, 2, 478-485.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H319

Harmful if swallowed. Causes serious eye irritation.

Precautionary Statements: P280-P264-P270-P305+P351+P338-P301+P312-P337+P313-P330-P501a

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. If eye irritation persists: Get medical advice/attention. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • A12739

    Oxalacetic acid, 97%
  • 13297

    Nickel single crystal, 18-20mm (0.71-0.79in) dia, 50mm (2.0in) long, (100) orientation
  • H31885

    3-Methyl-5-(trifluoromethoxy)cinnamic acid, 97%
  • B21960

    (-)-Diisopropyl-L-malate, 97%
  • H26973

    2-Chloro-6-methoxyquinoline-3-carboxaldehyde, 99%

Recently Viewed


Life Science

Metals & Materials


Analytical & Labware