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184901-82-4 - Tripeptidyl peptidase Inhibitor - H-AAF-CMK - TPPII Inhibitor - J64760 - Alfa Aesar

J64760 Tripeptidyl peptidase Inhibitor

CAS Number
184901-82-4
Synonyms
H-AAF-CMK
TPPII Inhibitor

Size Price ($) Quantity Availability
5mg 73.71
10mg 175.00
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Tripeptidyl peptidase Inhibitor

MDL
MFCD01310850

Chemical Properties

Formula
C16H22ClN3O3
Formula Weight
453.90
Form
Solid
Sensitivity
Light Sensitive
Solubility
Soluble in water.

Applications

Tripeptidyl peptidase Inhibitor is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions, and reversibly inhibits Cln (TPPI). AAF-CMK shows only marginal inhibition of the chymotrypsin-like activity of the proteasome.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers. It is sensitive to light.

Literature References

Ulrike Kuckelkorn.; Thomas Ruppert.; Britta Strehl.; Peter R. Jungblut.; Ursula Zimny-Arndt.; Stephanie Lamer.; Immo Prinz.; Ilse Drung.; Peter-M. Kloetzel.; Stefan H.E. Kaufmann.; Ulrich Steinhoff . Link between Organ-specific Antigen Processing by 20S Proteasomes and CD8+ T Cell-mediated Autoimmunity. JEM Home. 2002, 195, (8), 983.

Maria Luisa Gándara.; Pilar Lopez.; Raquel Hernando.; Jose G. Castano.; Susana Alemany. The COOH-Terminal Domain of Wild-Type Cot Regulates Its Stability and Kinase Specific Activity . The lancet. 1972, 299, (7750), 555-557.

Other References

Harmonized Tariff Code
3504.00
TSCA
No

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