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Compatible with cultured cell extracts or scaffold cells Osteocalcin is used as a bio-marker for the bone formation process. It is involved to study the effectiveness of a glycoprotein on bone formation used osteocalcin as a measure of osteoblast activity. It acts as a hormone in the body, causing beta cells in the pancreas to release more insulin. Further, it is used for the quantitative determination of intact human osteocalcin in serum and plasma samples using 96-well plates and a microplate reader.
Ferron, M.; Lacombe, J.; Germain, A.; Oury, F.; Karsenty, G. GGCX and VKORC1 inhibit osteocalcin endocrine functions. J. Cell Biol. 2015, 208 (6), 761-776.
Oury, F.; Ferron, M.; Huizhen, W.; Confavreux, C.; Xu, L.; Lacombe, J.; Srinivas, P.; Chamouni, A.; Lugani, F.; Lejeune, H.; Kumar, T. R. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J. Clin. Invest. 2015, 125 (5), 2180-2180.
Hazard Statements: H314-H302-H335
Causes severe skin burns and eye damage. Harmful if swallowed. May cause respiratory irritation.
Precautionary Statements: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.