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53-85-0 - 5,6-Dichlorobenzimidazole riboside, 98% - DBR - 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole - J64870 - Alfa Aesar

J64870 5,6-Dichlorobenzimidazole riboside, 98%

CAS Number
53-85-0
Synonyms
DBR
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole

Size Price ($) Quantity Availability
50mg 125.60
100mg 242.40
250mg 561.60
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5,6-Dichlorobenzimidazole riboside, 98%

MDL
MFCD00036785

Chemical Properties

Formula
C12H12Cl2N2O4
Formula Weight
319.14
Form
Powder
Solubility
Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.

Applications

Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases.

Notes

Incompatible with heat and oxidizing agents.

Literature References

Liu, Y.; He, X.; Sui, Y.; Yu, R.; Xu, G. Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition. FEBS Lett. 2015, 589 (17), 2233-2240.

Bartkowiak, B.; Greenleaf, A. L. Expression, Purification, and Identification of Associated Proteins of the Full-length hCDK12/CyclinK Complex. J. Biol. Chem. 2015, 290 (3), 1786-1795.

Other References

Beilstein
39123
Harmonized Tariff Code
2938.90
TSCA
No
RTECS
DD7310000

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