Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

1186653-73-5 - uPA Inhibitor II, UK122 - J64874 - Alfa Aesar

J64874 uPA Inhibitor II, UK122

CAS Number

Size Price ($) Quantity Availability
5mg 178.00
25mg 713.00
Add to Cart Add to Quote Request View Item

uPA Inhibitor II, UK122

Chemical Properties

Formula Weight
Light Sensitive
Soluble in dimethyl sulfoxide.


A cell-permeable oxazolidinone-carboxamidine compound that acts as a potent, selective, and active-site targeting inhibitor of urokinase-type plasminogen activatoruPA Inhibitor II, UK122 acts as a potent, selective and active-site targeting urokinase-type plasminogen activator (uPA) inhibitor. However, its activity against trypsin, thrombin, tPA, and plasmin is greatly reduced. It is also effectively inhibits the migration (80% inhibition) and invasion (68% inhibition) of uPA-expressing CFPAC-1 pancreatic cells, without affecting its proliferation.


Store in a cool place. Incompatible with oxidizing agents,.

Literature References

Mochida, S.; Tsuzuki, S.; Inouye, K.; Fushiki, T. A recombinant catalytic domain of matriptase induces detachment and apoptosis of small-intestinal epithelial IEC-6 cells cultured on laminin-coated surface. J. Biochem. 2010, 148 (6), 721-732.

Cho, E.; Lee, K. J.; Seo, J. W.; Byun, C. J.; Chung, S. J.; Suh, D. C.; Carmeliet, P.; Koh, J. Y.; Kim, J. S.; Lee, J. Y. Neuroprotection by urokinase plasminogen activator in the hippocampus. Neurobiol. Dis. 2012, 46 (1), 215-224.

GHS Hazard and Precautionary Statements

Precautionary Statements: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


Recently Viewed


Life Science

Metals & Materials


Analytical & Labware