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A cell-permeable oxazolidinone-carboxamidine compound that acts as a potent, selective, and active-site targeting inhibitor of urokinase-type plasminogen activatoruPA Inhibitor II, UK122 acts as a potent, selective and active-site targeting urokinase-type plasminogen activator (uPA) inhibitor. However, its activity against trypsin, thrombin, tPA, and plasmin is greatly reduced. It is also effectively inhibits the migration (80% inhibition) and invasion (68% inhibition) of uPA-expressing CFPAC-1 pancreatic cells, without affecting its proliferation.
Mochida, S.; Tsuzuki, S.; Inouye, K.; Fushiki, T. A recombinant catalytic domain of matriptase induces detachment and apoptosis of small-intestinal epithelial IEC-6 cells cultured on laminin-coated surface. J. Biochem. 2010, 148 (6), 721-732.
Cho, E.; Lee, K. J.; Seo, J. W.; Byun, C. J.; Chung, S. J.; Suh, D. C.; Carmeliet, P.; Koh, J. Y.; Kim, J. S.; Lee, J. Y. Neuroprotection by urokinase plasminogen activator in the hippocampus. Neurobiol. Dis. 2012, 46 (1), 215-224.