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The GHS-R (growth hormone secretagogue receptor) potently stimulates growth hormone release from the pituitary gland in vivo and in vitro. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. Ghrelin (human) is an activator of GHS-R1a.
Masayasu Kojima; Hiroshi Hosoda; Yukari Date; Masamitsu Nakazato; Hisayuki Matsuo; & Kenji Kangawa. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999, 402, 656-660.
Jesus A. Gutierrez; Patricia J. Solenberg; Douglas R. Perkins; Jill A. Willency; Michael D. Knierman; Zhaoyan Jin; Derrick R. Witcher; Shuang Luo; Jude E. Onyia and John E. Hale. Ghrelin octanoylation mediated by an orphan lipid transferase. Journal of Experimental Botany. 2008, 105,(17), 6320-6325.