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733767-34-5 - NSC 23766 - Rac1 Inhibitor - J64979 - Alfa Aesar

J64979 NSC 23766

CAS Number
733767-34-5
Synonyms
Rac1 Inhibitor

Size Price ($) Quantity Availability
10mg 146.00
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NSC 23766

MDL
MFCD08703096

Chemical Properties

Formula
C24H35N7•3HCl
Formula Weight
530.96
Form
Powder
Sensitivity
Light Sensitive & Hygroscopic
Solubility
Soluble in water.

Applications

The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compress investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.

Notes

Light Sensitive & Hygroscopic. Protect from heat. Store away from oxidizing agents.

Literature References

Whitney E. Hable.; Sriharshan Reddy.; Lindsay Julien. The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa. Planta. 2008, 227, (5), 991-1000.

Regina Gonzalez-Dosal.; Kristy A. Horan.; Soren R. Paludan. Mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a DNA virus, but not by an RNA virus. Biochemical and Biophysical Research Communications. 2012, 418, (4), 806-810.

Other References

Harmonized Tariff Code
2933.29
TSCA
No

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