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Useful in the study of endothelial cells and microglia. Also useful as a positive control of foam cell formation.Lipoprotein, low density, acetylated, human plasma is used for receptor binding to murine peritoneal macrophages. Further, it is taken up by macrophage and endothelial cells that possess scavenger receptors specific for the modified LDL.
Dai, Y.; Su, W.; Ding, Z.; Wang, X.; Mercanti, F.; Chen, M.; Raina, S.; Mehta, J. L. Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR- 2013, 431 (3), 496-500.
Michael, D. R.; Davies, T. S.; Laubertová, L.; Gallagher, H.; Ramji, D. P. The Phosphoinositide 3-Kinase Signaling Pathway is Involved in the Control of Modified Low-Density Lipoprotein Uptake by Human Macrophages. Lipids 2015, 50 (3), 253-260.
Zhang, Y.; Han, Q.; You, S.; Cao, Y.; Zhang, X.; Liu, H.; Hu, L.; Liu, C. F. Rapamycin Promotes the Autophagic Degradation of Oxidized Low-Density Lipoprotein in Human Umbilical Vein Endothelial Cells. J. Vasc. Res. 2015, 52 (3), 210-219.