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5536-17-4 - 9-beta-D-Arabinofuranosyladenine, 99% - Vidarabine - Ara-A - J65076 - Alfa Aesar

J65076 9-beta-D-Arabinofuranosyladenine, 99%

CAS Number
5536-17-4
Synonyms
Vidarabine
Ara-A

Size Price ($) Quantity Availability
1g 12.30
5g 41.40
25g 165.00
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9-beta-D-Arabinofuranosyladenine, 99%

MDL
MFCD00065471
EINECS
226-893-9

Chemical Properties

Formula
C10H13N5O4
Formula Weight
267.24
Form
Powder
Solubility
Soluble in DMF (10 mg/ml), 0.5 M HCl (50 mg/ml), DMSO (53 mg/ml at 25°C), ethanol (<1 mg/ml at 25°C), and water (3 mg/ml at 25°C).

Applications

Vidarabine is a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes. Vidarabine is an inhibitor of A cyclase and DNA Polymerase. Used to study the roles of AMP-activated protein kinase (AMPK) in cell signaling. Cell-permeable adenylate cyclase inhibitor; in detergent-dispersed rat brain preparation, IC50 = 30 ?M. Clinically significant antiviral agent, especially against herpes simplex (HSV),1 by inhibition of DNA polymerase.

Notes

Keep container tightly closed. Store away from oxidizing agents.

Literature References

Gene D. Morse.; Mark J. Shelton.; Alice M. O Donnell. Comparative Pharmacokinetics of Antiviral Nucleoside Analogues. Clinical Pharmacokinetics. 1993, 24, (2), 101-123.

John A. SecristIII.; Anita T. Shortnacy.; John A. Montgomery. Synthesis and biological evaluations of certain 2-halo-2'-substituted derivatives of 9-.beta.-D-arabinofuranosyladenine. J. Med. Chem. 1988, 31, (2), 405-410.

GHS Hazard and Precautionary Statements

Hazard Statements: H361

Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9976
Beilstein
624881
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
AU6200000

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