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J65110 Orexin B, human

CAS Number
Synonyms
Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Stock No. Size Price ($) Quantity Availability
J65110-!D 0.5mg 174.00
J65110-M^ 1mg 303.00
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Orexin B, human

MDL
MFCD01635373

Chemical Properties

Formula
C123H212N44O35S
Formula Weight
2899.33
Form
Lyophilized powder
Storage & Sensitivity
Store at -20°C. Light Sensitive.
Solubility
Soluble in water at 1mg/ml

Applications

Orexin is a neuropeptide that modulates the energy and metabolism balance. The effects of orexin are mediated by one of the two G protein-coupled receptors, orexin receptor 1 or 2. OXRs are expressed in oxinergic projection areas of the brain and regulate food intake by reducing systemic and brain signals that drive over-eating. Synthetic peptide corresponding to the C-terminus of human orexin receptor 1, conjugated to KLH. The immunizing peptide has 70% homology with the rat and mouse gene.

Notes

Protect from heat. Store away from oxidizing agents.

Literature References

Kousaku Ohno.; Takeshi Sakurai. Orexin neuronal circuitry: Role in the regulation of sleep and wakefulness. Frontiers in Neuroendocrinology. 2008, 29, (1), 70-87.

Katayama, S.; Hamasu, K.; Shigemi, K.; Cline, M.A.; Furuse, M. Intracerebroventricular injection of orexin-A, but not orexin-B, induces arousal of layer-type neonatal chicks. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2010, 157, (2), 132-135.

Other References

Merck
14,6866
Harmonized Tariff Code
2937.19
TSCA
No

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