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30516-87-1 - 3'-Azido-3'-deoxythymidine, 98% - AZT - Zidovudine - J65127 - Alfa Aesar

J65127 3'-Azido-3'-deoxythymidine, 98%

CAS Number
30516-87-1
Synonyms
AZT
Zidovudine

Size Price ($) Quantity Availability
1g 38.50
5g 115.00
25g 280.00
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3'-Azido-3'-deoxythymidine, 98%

MDL
MFCD00006536

Chemical Properties

Formula
C10H13N5O4
Formula Weight
267.24
Form
Powder
Melting point
113-115°
Sensitivity
Light Sensitive & Hygroscopic
Solubility
Soluble in water.

Applications

3'-Azido-3'-deoxythymidine is a Anti-viral agent, and also used as a reverse transcriptase inhibitor active against HIV-1 virus that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. 3?-Azido-3?-deoxythymidine enters CNS by diffusion and causes irreversible telomere shortening.

Notes

Light Sensitive & Hygroscopic. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Hashem Heiati.; Rashad Tawashi.; Nigel C Phillips. Solid lipid nanoparticles as drug carriers: II. Plasma stability and biodistribution of solid lipid nanoparticles containing the lipophilic prodrug 3?-azido-3?-deoxythymidine palmitate in mice. International Journal of Pharmaceutics. 1998, 174, (1-2), 71-80.

Chris Meier.; Eric De Clercq.; Jan Balzarini. Nucleotide Delivery from cycloSaligenyl-3?-azido-3?-deoxythymidine Monophosphates (cycloSal-AZTMP). European Journal of Organic Chemistry. 1998, 1998, (5), 837-846.

GHS Hazard and Precautionary Statements

Hazard Statements: H303-H351

May be harmful if swallowed. Suspected of causing cancer.

Precautionary Statements: P201-P280-P312a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Call a POISON CENTER/doctor if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,10123
Beilstein
3595791
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
XP207200

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