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3'-Azido-3'-deoxythymidine is a Anti-viral agent, and also used as a reverse transcriptase inhibitor active against HIV-1 virus that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. 3?-Azido-3?-deoxythymidine enters CNS by diffusion and causes irreversible telomere shortening.
Hashem Heiati.; Rashad Tawashi.; Nigel C Phillips. Solid lipid nanoparticles as drug carriers: II. Plasma stability and biodistribution of solid lipid nanoparticles containing the lipophilic prodrug 3?-azido-3?-deoxythymidine palmitate in mice. International Journal of Pharmaceutics. 1998, 174, (1-2), 71-80.
Chris Meier.; Eric De Clercq.; Jan Balzarini. Nucleotide Delivery from cycloSaligenyl-3?-azido-3?-deoxythymidine Monophosphates (cycloSal-AZTMP). European Journal of Organic Chemistry. 1998, 1998, (5), 837-846.
Hazard Statements: H315-H319-H335-H341-H351
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Suspected of causing genetic defects. Suspected of causing cancer.
Precautionary Statements: P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant