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75607-67-9 - 9-beta-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate, 99% - Fludarabine monophosophate - 2-F-ara-AMP - J65154 - Alfa Aesar

J65154 9-beta-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate, 99%

CAS Number
75607-67-9
Synonyms
Fludarabine monophosophate
2-F-ara-AMP

Size Price ($) Quantity Availability
250mg 27.44
1g 128.75
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9-beta-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate, 99%

MDL
MFCD00866418

Chemical Properties

Formula
C10H13FN5O7P
Formula Weight
365.21
Form
Powder
Solubility
Soluble in DMSO or water at 5mg/ml

Applications

A chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase-?, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat. Store in refrigerator.

Literature References

L E Robertson; M J Keating. Fludarabine phosphate in the treatment of chronic lymphocytic leukemia: biology, clinical impact, and future directions. Cancer treatment and research. 1993, 64, 105-119.

W Plunkett; P Huang; V Gandhi. Metabolism and action of fludarabine phosphate. Seminars in Oncology. 1990, 17, (5 Suppl 8), 3-17.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2934.99
TSCA
No
RTECS
UO7440900

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