Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

J65154 9-beta-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate, 99%

CAS Number
75607-67-9
Synonyms
Fludarabine monophosophate
2-F-ara-AMP

Stock No. Size Price ($) Quantity Availability
J65154-MD 250mg 34.80
J65154-03 1g 125.00
Add to Cart Bulk/Specialty Print Quote View Item

9-beta-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate, 99%

MDL
MFCD00866418

Chemical Properties

Formula
C10H13FN5O7P
Formula Weight
365.21
Form
Powder
Storage & Sensitivity
Keep Cold.
Solubility
Soluble in DMSO or water at 5mg/ml

Applications

A chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase-?, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat. Store in refrigerator.

Literature References

L E Robertson; M J Keating. Fludarabine phosphate in the treatment of chronic lymphocytic leukemia: biology, clinical impact, and future directions. Cancer treatment and research. 1993, 64, 105-119.

W Plunkett; P Huang; V Gandhi. Metabolism and action of fludarabine phosphate. Seminars in Oncology. 1990, 17, (5 Suppl 8), 3-17.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2934.99
TSCA
No
RTECS
UO7440900

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware