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102121-60-8 - AM 580 - 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid - J65155 - Alfa Aesar

J65155 AM 580

CAS Number
102121-60-8
Synonyms
4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid

Size Price ($) Quantity Availability
10mg 109.00
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AM 580

MDL
MFCD00673916

Chemical Properties

Formula
C22H25NO3
Formula Weight
351.44
Form
Crystalline solid
Solubility
Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).

Applications

Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation. AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β. This receptor increases the expression of disintegrin and metalloprotease.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat. Store in refrigerator.

Literature References

S C Brooks; S Kazmer; A A Levin; A Yen. Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs. Blood . 1996, 87, (1), 227-237.

M Gianni; M Li Calzi; M Terao; G Guiso; S Caccia; T Barbui; A Rambaldi; E Garattini.AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996, 87, (4), 1520-1531.

Other References

Harmonized Tariff Code
2924.29
TSCA
No
RTECS
DH6834890

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