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51050-59-0 - 3,4-Dichloroisocoumarin, 99% - 3,4-Dichloro-2-benzopyran-1-one - 3,4-DCI - J65198 - Alfa Aesar

J65198 3,4-Dichloroisocoumarin, 99%

CAS Number
51050-59-0
Synonyms
3,4-Dichloro-2-benzopyran-1-one
3,4-DCI

Size Price ($) Quantity Availability
10mg 253.91
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3,4-Dichloroisocoumarin, 99%

MDL
MFCD00036960

Chemical Properties

Formula
C9H4Cl2O2
Formula Weight
215.03
Form
Powder
Solubility
Soluble in DMF or DMSO at a concentration of 10mM

Applications

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. It is an inhibitor of Chymotrypsin and Trypsin. ,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases.

Notes

Effective concentration 5-100 M. 3,4-DCI has a half life of 20 minutes at pH 7.5.

Literature References

Nadia Korfali; Elizabeth A L Fairley; Selene K Swanson; Laurence Florens; Eric C Schirmer. Use of sequential chemical extractions to purify nuclear membrane proteins for proteomics identification. Methods in Molecular Biology. 2009, 528, 201-225.

J W Harper; K Hemmi; J C Powers. Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor. Biochemistry (Washington). 1985, 24, (8), 1831-1841.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
6802625
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2932.20
TSCA
No

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