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1428-67-7 - Diarylpropionitrile - DPN - 2,3-Bis(4-hydroxyphenyl)-propionitrile - J65207 - Alfa Aesar

J65207 Diarylpropionitrile

CAS Number
1428-67-7
Synonyms
DPN
2,3-Bis(4-hydroxyphenyl)-propionitrile

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Diarylpropionitrile

MDL
MFCD01695412

Chemical Properties

Formula
C15H13NO2
Formula Weight
239.27
Form
Powder
Solubility
Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25°C).

Applications

DPN protects WT and ARKO mice and significantly decreases IL-1β following LPS treatment in young adult-derived microglia. DPN also elevates Bax expression. DPN induces a dose-dependent increase on vitellogenin synthesis. PPT and DPN are effective in dynamically, but differentially regulating intracellular calcium signaling in hippocampal neurons. DPN is more efficacious than PPT in potentiating a physiological concentration of glutamate-induced intracellular Ca2+ rise in these neurons. DPN prevents the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat. Store in refrigerator.

Literature References

Danielle K Lewis; Adam B Johnson; Shannon Stohlgren; Ashley Harms; Farida Sohrabji; Danielle K. Lewis; Adam B. Johnson; Shannon Stohlgren; Ashley Harms; Farida Sohrabji. Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats. Journal of Neuroimmunology. 2008, 195, (1), 47-59.

Inna Meltser; Yeasmin Tahera; Evan Simpson; Malou Hultcrantz; Konstantina Charitidi; Jan-Ake Gustafsson; and Barbara Canlon. Estrogen receptor β protects against acoustic trauma in mice. J Clin Invest. 2008, 118, (4), 1563-1570.

GHS Hazard and Precautionary Statements

Hazard Statements: H400-H319

Very toxic to aquatic life. Causes serious eye irritation.

Precautionary Statements: P273-P280-P264-P305+P351+P338-P337+P313-P391-P501a

Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Collect spillage. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
9
Packing Group
III
Harmonized Tariff Code
2926.90
TSCA
No
RTECS
UG0900000

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