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Oxidized LDL induces foam cell formation in some macrophage cell lines. Research on foam cell formation is relevant to the study of atherosclerosis. Cellular exposure to ox-LDL results is the formation of lipid droplets containing cholesteryl esters in the cytoplasm of the macrophage as the lipoprotein particles are metabolized by the cell.Lipoprotein, low density, oxidized, human plasma, is used to induce foam cell formation in macrophages.
Amézaga, N.;, Sanjurjo, L.; Julve, J.; Aran, G.; Pérez-Cabezas, B.; Bastos-Amador, P.; Armengol, C.; Vilella, R.; Escolà-Gil, J. C.; Blanco-Vaca, F.; Borràs, F. E.; Valledor, A. F.; Sarrias, M. R. Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptakeJ Leukoc Biol 2014, 95 (3), 509-520.
Haller, E.; Lindner, W.; Lämmerhofer, M. Gold nanoparticle-antibody conjugates for specific extraction and subsequent analysis by liquid chromatography-tandem mass spectrometry of malondialdehyde-modified low density lipoprotein as biomarker for cardiovascular risk. Anal. Chim. Acta 2015, 857, 53-63.
Zhong, Q.; Zhao, S.; Yu, B.; Wang, X.; Matyal, R.; Li, Y.; Jiang, Z. High-density Lipoprotein Increases the Uptake of Oxidized Low Density Lipoprotein via PPARgamma/CD36 Pathway in Inflammatory Adipocytes. Int. J. Biol. Sci. 2015, 11 (3), 256-265.