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J65298 FBPase-1 Inhibitor

CAS Number
883973-99-7
Synonyms
F16BPase Inhibitor

Stock No. Size Price ($) Quantity Availability
J65298-MA 10mg 127.00
J65298-MF 50mg 527.00
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FBPase-1 Inhibitor

MDL
MFCD22581250

Chemical Properties

Formula
C13H7Cl3N2O3S
Formula Weight
377.60
Form
Solid
Storage & Sensitivity
Keep Cold. Light Sensitive.
Solubility
Soluble in DMSO

Applications

FBPase-1 Inhibitor that inhibits hFBPase-1 enzymatic activity by competing at the AMP allosteric binding site. FBPase-1 Inhibitor has been shown to block glucose production in starved rat hepatoma cells.

Notes

Light sensitive. Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, light. Store in refrigerator.

Literature References

Chunqiu Lai; Rebecca J. Gum; Melissa Daly; Elizabeth H. Fry; Charles Hutchins; Celerino Abad-Zapatero; Thomas W. von Geldern. Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorganic & Medicinal Chemistry Letters. 2006, 16, (7), 1807-1810.

Thomas W. von Geldern; Chunqiu Lai; Rebecca J. Gum; Melissa Daly; Chaohong Sun; Elizabeth H. Fry; Celerino Abad-Zapatero. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. Bioorganic & Medicinal Chemistry Letters. 2006, 16, (7), 1811-1815.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
3504.00
TSCA
No

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