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J65341 Necrostatin-1

CAS Number
4311-88-0
Synonyms
Nec-1
Necroptotic Inhibitor

Stock No. Size Price ($) Quantity Availability
J65341-F+ 20mg 106.00
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Necrostatin-1

MDL
MFCD00056916

Chemical Properties

Formula
C13H13N3OS
Formula Weight
259.33
Form
Powder
Storage & Sensitivity
Keep Cold. Light Sensitive.
Solubility
Soluble in DMSO (10-25 mg/ml), 100% ethanol (6 mg/ml), and methanol (5 mg/ml).

Applications

Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.

Notes

Light sensitive. Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, light. Store in refrigerator.

Literature References

T Suzuki; T Tomioka; K Tuzimura. Proton nuclear magnetic resonance studies on methylthiohydantoins, thiohydantoins, and hydantoins of amino acids. Canadian journal of biochemistry. 1977, 55, (5), 521-527.

Mabel Lum; Renato Morona. Dynamin-related protein Drp1 and mitochondria are important forShigella flexneriinfection. International Journal of Medical Microbiology. 2014, 304, (5-6), 530-541.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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