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Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.
T Suzuki; T Tomioka; K Tuzimura. Proton nuclear magnetic resonance studies on methylthiohydantoins, thiohydantoins, and hydantoins of amino acids. Canadian journal of biochemistry. 1977, 55, (5), 521-527.
Mabel Lum; Renato Morona. Dynamin-related protein Drp1 and mitochondria are important forShigella flexneriinfection. International Journal of Medical Microbiology. 2014, 304, (5-6), 530-541.