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134448-10-5 - Cathepsin B Inhibitor III - CA-074 - [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline - J65347 - Alfa Aesar

J65347 Cathepsin B Inhibitor III

CAS Number
134448-10-5
Synonyms
CA-074
[L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline

Size Price ($) Quantity Availability
5mg 300.76
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Cathepsin B Inhibitor III

MDL
MFCD00797531

Chemical Properties

Formula
C18H29N3O6
Formula Weight
383.44
Form
Powder
Solubility
Soluble in methanol at 1mg/ml. Also soluble in DMSO or ethanol.

Applications

CA-074 is a potent and specific inhibitor of cathepsin B in vitro.

Notes

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, bases, heat. Store in refrigerator.

Literature References

Lasse Foghsgaard; Dorte Wissing; Daniel Mauch; Ulrik Lademann; Lone Bastholm; Marianne Boes; Folmer Elling; Marcel Leist and Marja Jaattela. Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor. JCB. 2001, 153, (5), 999-1010 .

Sajani S Lakka; Christopher S Gondi; Niranjan Yanamandra; William C Olivero; Dzung H Dinh; Meena Gujrati and Jasti S Rao. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene. 2004, 23, 4681-4689.

Other References

Harmonized Tariff Code
2934.99
TSCA
No

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