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CA-074 is a potent and specific inhibitor of cathepsin B in vitro.
Lasse Foghsgaard; Dorte Wissing; Daniel Mauch; Ulrik Lademann; Lone Bastholm; Marianne Boes; Folmer Elling; Marcel Leist and Marja Jaattela. Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor. JCB. 2001, 153, (5), 999-1010 .
Sajani S Lakka; Christopher S Gondi; Niranjan Yanamandra; William C Olivero; Dzung H Dinh; Meena Gujrati and Jasti S Rao. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene. 2004, 23, 4681-4689.