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appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds. Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety. It activates the orexin-1 and -2 receptors with equal affinity.
R.J. Rodgers; Y. Ishii; J.C.G. Halford; J.E. Blundell. Orexins and appetite regulation. Neuropeptides. 2002, 36, (5), 303-325.
Schwartz, M.W. Orexins and appetite: The big picture of energy homeostasis gets a little bigger. Nat Med. 1998, 4, 385-386.