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182498-32-4 - SB 225002 - 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea - J65387 - Alfa Aesar

J65387 SB 225002

CAS Number

Size Price ($) Quantity Availability
5mg 123.00
10mg 181.07
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SB 225002


Chemical Properties

Formula Weight
Moisture Sensitive
Soluble to 100mM in DMSO and to 50mM in ethanol


SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.


Moisture sensitive. Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, water/ moisture. Store in refrigerator.

Literature References

Julie Catusse; Anne Liotard; Bruno Loillier; Didier Pruneau; Jean-Luc Paquet. Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen α (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. Biochemical Pharmacology. 2003, 65, (5), 813-821.

John R. White; Judithann M. Lee; Peter R. Young; Robert P. Hertzberg; Anthony J. Jurewicz; Margery A. Chaikin; Katherine Widdowson; James J. Foley; Lenox D. Martin; Don E. Griswold and Henry M. Sarau. Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration. The Journal of Biological Chemistry. 1998, 273, 10095-10098.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • H56754

    3-Chloro-N-(4-fluorobenzyl)aniline, 97%
  • B22521

    5-Chloro-1-(4-piperidinyl)-2-benzimidazolidinone, 98%
  • J67734

    Protein Mass Spec Certified Standards Assortment
  • L15040

    Pyridine-3-boronic acid
  • A14734

    trans-Chalcone, 97%

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