Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

J65505 Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone

CAS Number
Synonyms
Z-IETD-FMK
Caspase-8 inhibitor

Stock No. Size Price ($) Quantity Availability
J65505-M^ 1mg 230.00
Add to Cart Add to Quote Request View Item

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone

MDL
MFCD01861686

Chemical Properties

Formula
C30H43FN4O11
Formula Weight
654.68
Form
Powder
Storage & Sensitivity
Store at -20°C. Moisture Sensitive. Store under Nitrogen.
Solubility
Soluble in DMSO

Applications

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.

Notes

Moisture sensitive. Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, water/ moisture. Store in refrigerator.

Literature References

Quinn L. Deveraux; Natalie Roy; Henning R. Stennicke; Todd Van Arsdale; Qiao Zhou; Srinivasa M. Srinivasula; Emad S. Alnemri; Guy S. Salvesen; John C. Reed. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. The EMBO Journal. 1998, 17, (8), 2139 - 2449.

Li Yu; Ajjai Alva; Helen Su; Parmesh Dutt; Eric Freundt; Sarah Welsh; Eric H. Baehrecke; Michael J. Lenardo. Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8. Science. 2011, 304, (5676), 1500-1502.

Other References

Harmonized Tariff Code
2924.29
TSCA
No

Recommended

  • H32844

    Methyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate hydrate, 97%
  • B24352

    4-Bromo-2-fluorobenzenesulfonyl chloride, 98%
  • A19090

    2-Methyl-2-pentanol, 99%
  • 39301

    Neodymium(III) 1,1,1-trifluoro-2,4-pentanedionate
  • B22613

    Silver cyclohexanebutyrate, 99% (dry wt.)

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware