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Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone - Z-IETD-FMK - Caspase-8 inhibitor - J65505 - Alfa Aesar

J65505 Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone

CAS Number
Synonyms
Z-IETD-FMK
Caspase-8 inhibitor

Size Price ($) Quantity Availability
1mg 235.00
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Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone

MDL
MFCD01861686

Chemical Properties

Formula
C30H43FN4O11
Formula Weight
654.68
Form
Powder
Sensitivity
Moisture Sensitive
Solubility
Soluble in DMSO

Applications

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.

Notes

Moisture sensitive. Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, water/ moisture. Store in refrigerator.

Literature References

Quinn L. Deveraux; Natalie Roy; Henning R. Stennicke; Todd Van Arsdale; Qiao Zhou; Srinivasa M. Srinivasula; Emad S. Alnemri; Guy S. Salvesen; John C. Reed. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. The EMBO Journal. 1998, 17, (8), 2139 - 2449.

Li Yu; Ajjai Alva; Helen Su; Parmesh Dutt; Eric Freundt; Sarah Welsh; Eric H. Baehrecke; Michael J. Lenardo. Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8. Science. 2011, 304, (5676), 1500-1502.

GHS Hazard and Precautionary Statements

Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2924.29
TSCA
No

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