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J65553 Protease Inhibitor Cocktail VII, for His Tag Sequences, DMSO-Free

CAS Number
Synonyms

Stock No. Size Price ($) Quantity Availability
J65553-LQ 1unit 93.50
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Protease Inhibitor Cocktail VII, for His Tag Sequences, DMSO-Free

Chemical Properties

Form
Lyophilized solid
Storage & Sensitivity
Store at -20°C. Hygroscopic.
Solubility
Insoluble in water.

Applications

AEBSF and Aprotinin act to inhibit serine proteases, including trypsin, chymotrypsin, and plasmin amongst others. Bestatin inhibits aminpeptidases. E-64 acts against cystein proteases. Leupeptin acts against both serine and cystein proteases. Pepstatin A inhibits acid proteases.

Notes

When reconstituted to 1ml, 1 unit makes a solution containing 100 mM AEBSF.HCl, 5mM bestatin, 1.5mM E-64, 2mM pepstatin A and 200uM phosphoramidon disodium salt

Literature References

R B Kim; M F Fromm; C Wandel; B Leake; A J Wood; D M Roden; and G R Wilkinson. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998, 101, (2), 289-294.

David L. Paterson, MB, BS, FRACP; Susan Swindells, MD; Jeffrey Mohr, MSW; Michelle Brester, RN; Emanuel N. Vergis, MD; Cheryl Squier, RN; Marilyn M. Wagener, MPH; and Nina Singh, MD. Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection. Ann Intern Med. 2000, 133, (1), 21-30.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
8
Packing Group
III
Harmonized Tariff Code
3822.00
TSCA
No

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