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Lipoprotein, low density, oxidized, human plasma, is evaluated for receptor binding to peritoneal macrophages. Furthermore, it is used to induce foam cell formation in macrophages.
Research on foam cell formation is relevant to the study of atherosclerosis. Cellular exposure to ox-LDL results in the formation of lipid droplets containing cholesteryl esters in the cytoplasm of the macrophage as the lipoprotein particles are metabolized by the cell.
Amezaga, N.; Sanjurjo, L.; Julve, J.; Aran, G.; Perez-Cebezas, B.; Bastos-Amador, P.; Armengol, C.; Vilella, R.; Escola-Gil, J. C.; Blanco-Vaca, F.; Borras, F. E.; Valledor, A. F.; Sarrias, M. -R. Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake. J Leukoc Bio 2013, 95 (3), 509-520.
Zhang, Y.; Ye, Y.; Wang, Y.; Chen, W. Inhibition of Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Protects against Plasma/Hypoxia-Mediated Trophoblast Dysfunction Associated with Preeclampsia. Gynecol. Obstet. Invest. 2013, 79 (2), 90-96.
Zhang, Y.; Xie, Y.; You, S.; Han, Q.; Cao, Y.; Zhang, X.; Xiao, G.; Chen, R.; Liu, C. Autophagy and Apoptosis in the Response of Human Vascular Endothelial Cells to Oxidized Low-Density Lipoprotein. Cardiology 2015, 132 (1), 27-33.