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J65591 Lipoprotein, low density, oxidized, human plasma, 99%, BT-910

**Product Being Discontinued…Please See Below**

CAS Number
Synonyms
Ox-LDL
Oxidized LDL

Stock No. Size Price ($) Quantity Availability
J65591-8+ 2mg 240.00
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Lipoprotein, low density, oxidized, human plasma, 99%, BT-910

Chemical Properties

Form
Liquid
Storage & Sensitivity
Keep Cold.

Grade Specifications

We are discontinuing the lipoprotein reagents that are currently sold under the Alfa Aesar brand.

For future orders, Thermo Fisher Scientific offers high-quality lipoprotein reagents under the Invitrogen™ and Gibco™ brands.

The available replacement can be found here: Invitrogen™ Low Density Lipoprotein from Human Plasma, oxidized (OxLDL)

Applications

Lipoprotein, low density, oxidized, human plasma, is evaluated for receptor binding to peritoneal macrophages. Furthermore, it is used to induce foam cell formation in macrophages.

Research on foam cell formation is relevant to the study of atherosclerosis. Cellular exposure to ox-LDL results in the formation of lipid droplets containing cholesteryl esters in the cytoplasm of the macrophage as the lipoprotein particles are metabolized by the cell.

Notes

Supplied at 2mg/ml in 1X phosphate-buffered saline at pH 7.4 and 0.3 mM EDTA. Contains gentamicin sulfate. Aseptically packaged and sterile filtered. Store at 4°C. Do not freeze. Short shelf life: up to 6 weeks. TBARS: 29-44 nmoles MDA/mg

Literature References

Amezaga, N.; Sanjurjo, L.; Julve, J.; Aran, G.; Perez-Cebezas, B.; Bastos-Amador, P.; Armengol, C.; Vilella, R.; Escola-Gil, J. C.; Blanco-Vaca, F.; Borras, F. E.; Valledor, A. F.; Sarrias, M. -R. Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake. J Leukoc Bio 2013, 95 (3), 509-520.

Zhang, Y.; Ye, Y.; Wang, Y.; Chen, W. Inhibition of Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Protects against Plasma/Hypoxia-Mediated Trophoblast Dysfunction Associated with Preeclampsia. Gynecol. Obstet. Invest. 2013, 79 (2), 90-96.

Zhang, Y.; Xie, Y.; You, S.; Han, Q.; Cao, Y.; Zhang, X.; Xiao, G.; Chen, R.; Liu, C. Autophagy and Apoptosis in the Response of Human Vascular Endothelial Cells to Oxidized Low-Density Lipoprotein. Cardiology 2015, 132 (1), 27-33.

Other References

Harmonized Tariff Code
3002.19
TSCA
No

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