Tris(hydroxymethyl)aminomethane is used as buffers in biochemistry and molecular biology laboratories. It is used as a primary standard to standardize acid solutions for chemical analysis. It finds application in cell membranes to increase its permeability. As an alternative to sodium bicarbonate, it used in the treatment of metabolic acidosis. It acts as a precursor for the preparation of polymers, oxazolones and oxazolidines.
Gharamaleki, V. J; Gharamaleki, K. J.; Soleymani, J.; Acree Jr, W. E.; Kenndler, E.; Jouyban, A. Solubility of Tris (hydroxymethyl) aminomethane in Water+ Methanol+ 1-Propanol Mixtures at Various Temperatures. J. Chem. Eng. Data 2015, 60 (8), 2515-2520.
Devi, M.; Dhir, A.; Pradeep, C. P. A Tris (hydroxymethyl) aminomethane-Rhodamine Spirolactam Derivative as Dual Channel pH and Water Sensor and Its Application to Bio Imaging. Eur. J. Org. Chem. 2015, 2015 (21), 4650-4657.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.