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GM 6001 is used to inhibits a wide variety of matrix metalloproteases with Kis in the nanomolar range. Active in a number of animal models of diseases where matrix metalloproteases are thought to be involved.
Damian Grobelny.; Louis Poncz.; Richard E. Galardy. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992, 31, (31), 7152-7154..
Chintda Santiskulvong.; Enrique Rozengurt. Galardin (GM 6001), a broad-spectrum matrix metalloproteinase inhibitor, blocks bombesin- and LPA-induced EGF receptor transactivation and DNA synthesis in rat-1 cells. Experimental Cell Research. 2003, 290, (2), 437-446..