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142880-36-2 - GM 6001 - Galardin - N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide - J65687 - Alfa Aesar

J65687 GM 6001

CAS Number
142880-36-2
Synonyms
Galardin
N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide

Size Price ($) Quantity Availability
1mg 86.50
5mg 311.00
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GM 6001

MDL
MFCD03453614

Chemical Properties

Formula
C20H28N4O4
Formula Weight
388.50
Form
Solid
Sensitivity
Moisture Sensitive
Solubility
Soluble in DMSO, and 100% ethanol.

Applications

GM 6001 is used to inhibits a wide variety of matrix metalloproteases with Kis in the nanomolar range. Active in a number of animal models of diseases where matrix metalloproteases are thought to be involved.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Damian Grobelny.; Louis Poncz.; Richard E. Galardy. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992, 31, (31), 7152-7154..

Chintda Santiskulvong.; Enrique Rozengurt. Galardin (GM 6001), a broad-spectrum matrix metalloproteinase inhibitor, blocks bombesin- and LPA-induced EGF receptor transactivation and DNA synthesis in rat-1 cells. Experimental Cell Research. 2003, 290, (2), 437-446..

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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