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Omi/HtrA2 Protease Inhibitor - High Temperature Requirement A2 Inhibitor I - 5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione - J65767 - Alfa Aesar

J65767 Omi/HtrA2 Protease Inhibitor

CAS Number
Synonyms
High Temperature Requirement A2 Inhibitor I
5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Size Price ($) Quantity Availability
10mg 154.00
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Omi/HtrA2 Protease Inhibitor

MDL
MFCD01000361

Chemical Properties

Formula
C27H17N3O5S
Formula Weight
495.50
Form
Solid
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO at 5mg/ml

Applications

A cell-permeable furfurylidine-thiobarbituric acid. Also small molecule/inhibitor is primarily used for Cancer applications.

Notes

Light Sensitive, store in dark. Keep the container tightly closed. Store away from oxidizing agent.

Literature References

Srinivasa M. Srinivasula; Sanjeev Gupta; Pinaki Datta; ZhiJia Zhang; Ramesh Hegde; NaEun Cheong; Teresa Fernandes-Alnemri; and Emad S. Alnemri. Inhibitor of Apoptosis Proteins Are Substrates for the Mitochondrial Serine Protease Omi/HtrA2. The Journal of Biological Chemistry, 2003 , 27831469-31472.

Y Suzuki; K Takahashi-Niki; T Akagi; T Hashikawa; and R Takahashi. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death and Differentiation, 2004, 11 208-216.

GHS Hazard and Precautionary Statements

Precautionary Statements: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
3504.00
TSCA
No

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