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208255-80-5 - DAPT - LY-374973 - N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine tert-butyl ester - J65864 - Alfa Aesar

J65864 DAPT

CAS Number
208255-80-5
Synonyms
LY-374973
N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine tert-butyl ester

Size Price ($) Quantity Availability
10mg 173.00
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DAPT

MDL
MFCD04974585

Chemical Properties

Formula
C23H26F2N2O4
Formula Weight
432.50
Form
Lyophilized
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO, ethanol, dichloromethane, DMF.

Applications

DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Qian Hua.; Ye Zhiwen.; Lv Chunxu. Ultrasonically promoted nitrolysis of DAPT to HMX in ionic liquid. Ultrasonics Sonochemistry. 2008, 15, (4), 326-329.

Jayanthi, S.; Madhu, P.K.; Ramanathan, K.V. Measurement of Carbon-Proton Dipolar Couplings in Liquid Crystals Using DAPT. J. Phys. Chem. A. 2008, 112, (44), 11159-11164.

Other References

Harmonized Tariff Code
2924.29
TSCA
No

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