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65144-34-5 - Elastase Inhibitor III - HLE Inhibitor - MeOSuc-AAPV-CMK - J65894 - Alfa Aesar

J65894 Elastase Inhibitor III

Elastase inhibitor III, or MeOSuc-Ala-Ala-Pro-Val chloromethyl ketone, inhibits human leukocyte elastase (HLE). It is cell permeable and because of the chloromethyl ketone group, it irreversibly inhibits the enzyme. HLE is a serine protease found in the azurophilic granules of polymorphononuclear leukocytes. When then enzyme is released from the cell it can hydrolyze elastin and collagen. Increased HLE activity has been is associated with several diseases including rheumatoid arthritis and cystic fibrosis.

CAS Number
65144-34-5
Synonyms
HLE Inhibitor
MeOSuc-AAPV-CMK

Size Price ($) Quantity Availability
5mg 108.00
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Elastase Inhibitor III

MDL
MFCD00077136

Chemical Properties

Formula
C23H36ClN3O7
Formula Weight
503.00
Form
Solid
Sensitivity
Moisture Sensitive
Solubility
Soluble in methanol or DMSO

Applications

A potent irreversible inhibitor of human leukocyte elastase

Other References

Harmonized Tariff Code
3504.00
TSCA
No

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