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Elastase inhibitor III, or MeOSuc-Ala-Ala-Pro-Val chloromethyl ketone, inhibits human leukocyte elastase (HLE). It is cell permeable and because of the chloromethyl ketone group, it irreversibly inhibits the enzyme. HLE is a serine protease found in the azurophilic granules of polymorphononuclear leukocytes. When then enzyme is released from the cell it can hydrolyze elastin and collagen. Increased HLE activity has been is associated with several diseases including rheumatoid arthritis and cystic fibrosis.
A potent irreversible inhibitor of human leukocyte elastase