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Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.
Franco Chimenti et. al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. Journal of medicinal and pharmaceutical chemistry, 2009,52(2), 530-536.
Kaveri Sidhu; Vijay Kumar. c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1849,111319-1328.