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87239-81-4 - Cefpodoxime proxetil, 96% - J66061 - Alfa Aesar

J66061 Cefpodoxime proxetil, 96%

CAS Number
87239-81-4
Synonyms

Size Price ($) Quantity Availability
1g 241.00
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Cefpodoxime proxetil, 96%

MDL
MFCD00865088

Chemical Properties

Formula
C21H27N5O9S2
Formula Weight
557.60
Form
Powder
Melting point
111-113°
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO

Applications

A broad spectrum antibiotic. Cefpodoxime proxetil is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Product is to be used for research and development only.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.

Cefpodoxime proxetil is a broad spectrum antibiotic which targets a wide variety of gram positive and gram negative bacteria especially those which cause otitis media and pharyngitis.

Literature References

Georgopapadakou, N. H. Mechanisms of Action of Cephalosporin 3'- quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli. American Society for Microbiology 1992, 37.3, 559-565.

Other References

Harmonized Tariff Code
2941.90
TSCA
No
RTECS
XI0367370

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