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93438-65-4 - Conantokin G - Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH<sub>2</sub> - J66100 - Alfa Aesar

J66100 Conantokin G

CAS Number
93438-65-4
Synonyms
Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2

Size Price ($) Quantity Availability
5mg 258.00
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Conantokin G

MDL
MFCD00214606

Chemical Properties

Formula
C88H138N26O44
Formula Weight
2264.18
Form
Solid
Solubility
Soluble in water at 1mg/ml

Applications

Non-competitive inhibitor of NMDA glutamatergic receptors acting at the polyamine site. Conantokin G (CGX-1007), a member of the conantokin family, is a selective NR2B subunit inhibitor of NMDA glutamatergic receptors with activity as a neuroprotective agent against NMDA-induced excitotoxicity.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Lance G. Hammerland.; Baldomero M. Olivera.; Doju Yoshikami. Conantokin-G selectively inhibits N-methyl-D-aspartate-induced currents in Xenopus oocytes injected with mouse brain mRNA. European Journal of Pharmacology: Molecular Pharmacology. 1992, 226, (3), 239-244.

Mary Prorok.; Scott E. Warder.; Tamas Blandl.; Francis J. Castellino. Calcium Binding Properties of Synthetic γ-Carboxyglutamic Acid-Containing Marine Cone Snail “Sleeper” Peptides, Conantokin-G and Conantokin-T. Biochemistry. 1996, 35, (51), 16528-16534.

GHS Hazard and Precautionary Statements

Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2925.29
TSCA
No
RTECS
GK5900000

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