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90105-47-8 - Ala-Ala-Pro-Val chloromethyl ketone, 95% - Ala-Ala-Pro-Val-CMK - J66149 - Alfa Aesar

J66149 Ala-Ala-Pro-Val chloromethyl ketone, 95%

CAS Number
90105-47-8
Synonyms
Ala-Ala-Pro-Val-CMK

Size Price ($) Quantity Availability
5mg 141.00
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Ala-Ala-Pro-Val chloromethyl ketone, 95%

MDL
MFCD00077092

Chemical Properties

Formula
C17H29ClN4O4
Formula Weight
388.89
Form
Solid
Solubility
Soluble in DMSO or DMF.

Applications

An irreversible and cell permeable inhibitor of human leukocyte elastase. Chloromethyl ketones covalently bond to the OH of an adjacent serine residue, or to the SH of an adjacent cysteine residue, on the target protein.

Notes

Dissolve in DMSO or DMF at 100mM for a stock solution. Dilute in buffer as needed. A twenty minute incubation is suggested for optimum inhibition.

Literature References

William C. Groutas. Inhibitors of leukocyte elastase and leukocyte Cathepsin G. Agents for the treatment of emphysema and related ailments. Medicinal Research Reviews. 1987, 7, (2), 227-241.

Wei An-Zhi.; Irmgard Mayr.; Wolfram Bode. The refined 2.3 Å crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor. FEBS Letters. 1988, 234, (2), 367-373.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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