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4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.
Ch. Meyer, J.; Grundmann, H.P.; Schnyder, U.W. Determination of arylsulfatase C in hair follicles. Archives of Dermatological Research. 1979, 266, (1), 95-97.
Rosa Bartolomeo.; Elena V. Polishchuk.; Nicola Volpi.; Roman S. Polishchuk.; Alberto Auricchio. Pharmacological read-through of nonsense ARSB mutations as a potential therapeutic approach for mucopolysaccharidosis VI. Archives of Dermatological Research. 2013, 36, (2), 363-371.