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J66160 4-Methylumbelliferyl sulfate potassium salt, 98%

CAS Number
15220-11-8
Synonyms

Stock No. Size Price ($) Quantity Availability
J66160-ME 500mg 100.00
J66160-03 1g 180.00
J66160-06 5g 360.00
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4-Methylumbelliferyl sulfate potassium salt, 98%

MDL
MFCD00016970
EINECS
239-272-2

Chemical Properties

Formula
C10H7KO6S
Formula Weight
294.32
Form
Powder
Storage & Sensitivity
Store at -20°C.
Solubility
Soluble in water at 5mg/ml

Applications

4-Methylumbelliferyl sulfate potassium salt is a fluorometric substrate for the determination of sulfatase. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.

Notes

Excitation wavelength, 334 nm; emission wavelength, 370nm (pH 10.4). Reaction product: excitiation wavelength, 360nm; emission wavelength, 449nm

Literature References

Ch. Meyer, J.; Grundmann, H.P.; Schnyder, U.W. Determination of arylsulfatase C in hair follicles. Archives of Dermatological Research. 1979, 266, (1), 95-97.

Rosa Bartolomeo.; Elena V. Polishchuk.; Nicola Volpi.; Roman S. Polishchuk.; Alberto Auricchio. Pharmacological read-through of nonsense ARSB mutations as a potential therapeutic approach for mucopolysaccharidosis VI. Archives of Dermatological Research. 2013, 36, (2), 363-371.

Other References

Beilstein
3803203
Harmonized Tariff Code
2932.20
TSCA
Yes

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