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70476-82-3 - Mitoxantrone dihydrochloride - 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride - J66341 - Alfa Aesar

J66341 Mitoxantrone dihydrochloride

CAS Number
70476-82-3
Synonyms
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

Size Price ($) Quantity Availability
50mg 117.00
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Mitoxantrone dihydrochloride

MDL
MFCD00242943
EINECS
274-619-1

Chemical Properties

Formula
C22H28N4O6.2HCl
Formula Weight
517.40
Form
Crystalline solid
Solubility
Soluble to 5 mM in water and to 75 mM in DMSO

Applications

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

Geoffrey R. Fisher.; Laurence H. Patterson. DNA strand breakage by peroxidase-activated mitoxantrone. Journal of Pharmacy and Pharmacology. 1991, 43, (1), 65-68.

Reginald Hulhoven.; Etienne Dumont.; Carl Harvengt. Plasma kinetics of mitoxantrone in leukemic patients. Medical Oncology and Tumor Pharmacotherapy. 1984, 3, (1), 201-204.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H310-H340-H360

Harmful if swallowed. Fatal in contact with skin. May cause genetic defects. May damage fertility or the unborn child.

Precautionary Statements: P260-P201-P280h-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6217
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2922.50
TSCA
No
RTECS
CB5748500

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