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70476-82-3 - Mitoxantrone dihydrochloride - 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride - J66341 - Alfa Aesar

J66341 Mitoxantrone dihydrochloride

CAS Number
70476-82-3
Synonyms
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

Size Price ($) Quantity Availability
50mg 118.45
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Mitoxantrone dihydrochloride

MDL
MFCD00242943
EINECS
274-619-1

Chemical Properties

Formula
C22H28N4O6.2HCl
Formula Weight
517.40
Form
Crystalline solid
Solubility
Soluble to 5 mM in water and to 75 mM in DMSO

Applications

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

Geoffrey R. Fisher.; Laurence H. Patterson. DNA strand breakage by peroxidase-activated mitoxantrone. Journal of Pharmacy and Pharmacology. 1991, 43, (1), 65-68.

Reginald Hulhoven.; Etienne Dumont.; Carl Harvengt. Plasma kinetics of mitoxantrone in leukemic patients. Medical Oncology and Tumor Pharmacotherapy. 1984, 3, (1), 201-204.

GHS Hazard and Precautionary Statements

Hazard Statements: H310-H302-H340-H360

Fatal in contact with skin. Harmful if swallowed. May cause genetic defects. May damage fertility or the unborn child.

Precautionary Statements: P201-P262-P280-P281-P361-P302+P350-P310-P301+P312-P405-P501a

Obtain special instructions before use. Do not get in eyes, on skin, or on clothing. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6217
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2922.50
TSCA
No
RTECS
CB5748500

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