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Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.
Geoffrey R. Fisher.; Laurence H. Patterson. DNA strand breakage by peroxidase-activated mitoxantrone. Journal of Pharmacy and Pharmacology. 1991, 43, (1), 65-68.
Reginald Hulhoven.; Etienne Dumont.; Carl Harvengt. Plasma kinetics of mitoxantrone in leukemic patients. Medical Oncology and Tumor Pharmacotherapy. 1984, 3, (1), 201-204.
Hazard Statements: H302-H310-H340-H360
Harmful if swallowed. Fatal in contact with skin. May cause genetic defects. May damage fertility or the unborn child.
Precautionary Statements: P201-P262-P280-P310a-P405-P501a
Obtain special instructions before use. Do not get in eyes, on skin, or on clothing. Wear protective gloves/protective clothing/eye protection/face protection. Immediately call a POISON CENTER/doctor Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.