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Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.
Geoffrey R. Fisher.; Laurence H. Patterson. DNA strand breakage by peroxidase-activated mitoxantrone. Journal of Pharmacy and Pharmacology. 1991, 43, (1), 65-68.
Reginald Hulhoven.; Etienne Dumont.; Carl Harvengt. Plasma kinetics of mitoxantrone in leukemic patients. Medical Oncology and Tumor Pharmacotherapy. 1984, 3, (1), 201-204.
Hazard Statements: H302-H310-H340-H350-H360
Harmful if swallowed. Fatal in contact with skin. May cause genetic defects. May cause cancer. May damage fertility or the unborn child.
Precautionary Statements: P201-P202-P262-P264b-P270-P281-P301+P312-P302+P350-P308+P313-P310-P330-P361-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not get in eyes, on skin, or on clothing. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Gently wash with plenty of soap and water. IF exposed or concerned: Get medical advice/attention. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant