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Mupirocin is involved in inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. It also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
Andrew E Simor; Tammy L Stuart; Lisa Louie; Christine Watt; Marianne Ofner-Agostini; Denise Gravel; Michael Mulvey; Mark Loeb; Allison McGeer; Elizabeth Bryce; Anne Matlow. Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Antimicrobial Agents and Chemotherapy. 2007, 51, (11), 3880-3886.
Gaston H.M. Vondenhoff; Arthur Van Aerschot. Aminoacyl-tRNA synthetase inhibitors as potential antibiotics. European Journal of Medicinal Chemistry. 2011, 46, (11), 5227-5236.