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Adrenocorticotropic Hormone (1-24), human is used in the treatment of West syndrome. It activates G proteins. It stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells. It also enhances transcription of mitochondrial genes.
Y F Jacquet. Opiate effects after adrenocorticotropin or beta-endorphin injection in the periaqueductal gray matter of rats. Science.1978, 201, (4360), 1032-1034.
O Hochwald; L Holsti; H Osiovich. The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. Journal of Perinatology.2012, 32, (6), 412-417.