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Nisin, 900 I.U./mg is commonly used as a food preservative. It is also used as a selective agent in cell culture for the isolation of gram-negative bacteria, yeast, and molds. Nisin has been used in bioassays to study posttranslational modification. It binds and interferes with the permeability of the cytoplasmic membrane.
Product can bind to glass and polypropylene, can be prevented by using a surfactant, such as Polysorbate 80
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
Olli Koponen; Marja Tolonen; Mingqiang Qiao; Gudrun Wahlström; Jari Helin; Per E J Saris. NisB is required for the dehydration and NisC for the lanthionine formation in the post-translational modification of nisin. Microbiology. 2002, 148,(Pt 11), 3561-3568.
Brötz H.; and Sahl H. New insights into the mechanism of action of lantibiotics - Diverse biological effects by binding to the same molecular target. J Antimicrob Chemother. 2000, 46,(1), 1-6.