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84625-61-6 - Itraconazole, 98% - Oriconazole - R51211 - J66390 - Alfa Aesar

J66390 Itraconazole, 98%

CAS Number
84625-61-6
Synonyms
Oriconazole
R51211

Size Price ($) Quantity Availability
1g 72.10
5g 144.20
25g 596.00
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Itraconazole, 98%

MDL
MFCD00870168

Chemical Properties

Formula
C35H38Cl2N8O4
Formula Weight
705.63
Form
Powder
Melting point
166°
Flash Point
>110°(230°F)
Solubility
Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol

Applications

Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It?s different formulations are used to study Candida strains in murine invasive infections. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats..

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

Katsuhisa Uchida; Kosuke Shimogawara; Hideyo Yamaguchi. Correlation of in vitro activity and in vivo efficacy of itraconazole intravenous and oral solubilized formulations by testing Candida strains with various itraconazole susceptibilities in a murine invasive infection. Journal of Antimicrobial Chemotherapy.2011, 66, (3), 626-634.

Tomoya Sano; Kiyokazu Ozaki; Yasushi Kodama; Tetsuro Matsuura; Isao Narama. Effects of the antifungal agent itraconazole on proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats. Toxicologic Pathology.2009, 37, (6), 790-798.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5245
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
XZ5481000

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