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132-92-3 - Methicillin sodium salt, 98% - Sodium (2,6-dimethoxyphenyl)penicillin - Sodium methicillin - J66414 - Alfa Aesar

J66414 Methicillin sodium salt, 98%

CAS Number
132-92-3
Synonyms
Sodium (2,6-dimethoxyphenyl)penicillin
Sodium methicillin

Size Price ($) Quantity Availability
1g 185.40
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Methicillin sodium salt, 98%

MDL
MFCD07787409
EINECS
205-083-9

Chemical Properties

Formula
C17H19N2NaO6S
Formula Weight
402.40
Form
Powder
Melting point
196-197° dec.
Boiling Point
640°
Flash Point
>110°(230°F)
Sensitivity
Light Sensitive
Solubility
Slightly soluble in acetone. Soluble in ethanol or water

Applications

Targets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

Campanella, L.; Mazzei, F.; Sbrilli, R.; Tomassetti, M. Benzylpenicillin PVC membrane electrode for the determination of antibiotics in formulations. Journal of Pharmaceutical and Biomedical Analysis. 1988, 6, (3), 299-305.

Michael Averill Schwartz.; David E. Tutt. Model catalysts which stimulate penicillinase. V. The cycloheptaamylose-catalyzed hydrolysis of penicillins. J. Am. Chem. Soc. 1971, 93, (3), 767-772.

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H315-H319-H317-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.

Precautionary Statements: P285-P261-P280-P305+P351+P338-P304+P340-P342+P311-P362-P312-P405-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5969
Harmonized Tariff Code
2941.10
TSCA
No
RTECS
XH8950000

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