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Targets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.
Campanella, L.; Mazzei, F.; Sbrilli, R.; Tomassetti, M. Benzylpenicillin PVC membrane electrode for the determination of antibiotics in formulations. Journal of Pharmaceutical and Biomedical Analysis. 1988, 6, (3), 299-305.
Michael Averill Schwartz.; David E. Tutt. Model catalysts which stimulate penicillinase. V. The cycloheptaamylose-catalyzed hydrolysis of penicillins. J. Am. Chem. Soc. 1971, 93, (3), 767-772.
Hazard Statements: H315-H319-H334-H317-H335
Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. May cause respiratory irritation.
Precautionary Statements: P284-P261-P280a-P305+P351+P338-P405-P501a
Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.